I'm not quite sure what to make of Chris Hardwick and Mike Phirman, known together as Hard 'N Phirm. Their songs and videos include several with science/math themes, yet they don't seem to have an educational agenda per se. I guess maybe they see the communication of science simply as an area ripe with humorous satirical possibilities.
The song illustrated below, "El Corazón" (The Heart), seems sort of representative of their work. A passionate recitation of facts about the cardiovascular system, in Spanish, gives way to a quick tribute to the rock band Heart and then a depressing ending. You may want to watch it twice.